butabarbital decreases effects of sufentanil SL by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of CYP3A4 inducers might lessen sufentanil levels and efficacy, probably precipitating withdrawal syndrome in clients who've made Bodily dependence to sufentanil. Discontinuation of concomitantly